Alpha-Lipoic Acid Attenuates Renal Injury in Rats with Obstructive Nephropathy

Figure 3

Effects of unilateral ureteral obstruction (UUO) and alpha-lipoic acid (ALA) on renal histopathological changes in the obstructed kidney from sham ((a), H&E 40x; (d), Masson’s trichrome 40x) showing normal tubules and peritubular stromal tissues, UUO group ((b), H&E 40x; (e), Masson’s trichrome 40x) showing dilated tubules, marked interstitial infiltration with polymorphonuclear leukocytes and severe interstitial fibrosis, UUO + ALA group ((c), H&E 40x; (f), Masson’s trichrome 40x) showing mild leukocyte infiltration and less fibroblastic proliferation. The degree of leukocyte infiltration (g) and fibrotic area (h) are shown as mean ± SEM from 10 rats in each group. ^∗𝑃<0.01, ^∗∗𝑃<0.001 versus sham. ^†𝑃<0.001 versus UUO.

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