Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma

Table 2

Patient's clinical and pathological characteristics according to MRP1 and MRP4 expression as assessed by immunohistochemistry.

Clinical parameters; Total; (𝑛=127)	MRP1 expression						MRP4 expression
	Negative (𝑛=84)		Positive (𝑛=36)		Missing (𝑛=7)	𝑃^∗	Negative (𝑛=80)		Positive (𝑛=24)		Missing (𝑛=23)	𝑃^∗
	N°	%	N°	%			N°	%	N°	%
Age, years						0.245						0.971
≤55	40	75	13	25	2		33	77	10	23	12
>55	44	66	23	34	5		47	77	14	23	11
Tumor histotype						0.617						0.686
Serous	53	68	25	32	5		52	74	18	26	13
Undifferentiated	9	82	2	18	1		7	87	1	13	4
Clear cell	8	67	4	33			10	83	2	17
Endometrioid	8	67	4	33			6	67	3	33	3
Mucinous	5	100			1		3	100			3
Others	1	50	1	50			2	100
Tumor stage (FIGO)						0.178						0.172
I + II	30	79	8	21	1		30	83	6	17	3
III	40	69	18	31	6		36	78	10	22	18
IV	13	57	10	43			13	62	8	38	2
Missing	1						1
Tumor grade						0.037						0.821
1	7	78	2	22			5	83	1	17	3
2	37	80	9	20	2		32	74	11	26	5
3	27	55	22	45	4		31	74	11	59	11
Undifferentiated	9	82	2	18	1		7	87	1	13	4
Missing	4		1				5
Amount of residual disease						0.32						0.29
NED	33	75	11	25	3		31	82	7	18	9
<1 cm	12	67	6	33	1		10	62	6	38	3
>1 cm	27	60	18	40	1		26	70	11	30	9
Missing	12		1		2		13				2

NED: not evidence of disease. ^∗𝑃 values: evaluated on MRP1 and MRP4 expression and available clinical and pathological parameters.