Table 5: Multivariable analysis of the prognostic impact of clinical covariates and MRPs on progression free survival in high-grade EOC.

HR(95% CI)

 III-IV versus I-II <0.0001 10.53.56–30.8
 Serous versus
0.96 0.980.47–2.05
Surgical debulking
 SOD versus OD0.016 2.221.16–4.26
Age at diagnosis
 >55 versus ≤550.07 0.570.3–1.3
MRP1 expression
 Positive versus
0.11 0.580.31–1.13
MRP4 expression
 Positive versus
0.045 2.051.01–4.11

P value determined using log rank test; HR: hazard ratio; CI: confidence interval; SOD: suboptimal debulking (residual disease >1 cm), OD: optimal debulking (residual disease not evident or <1 cm).