Pre- and Postsynaptic Dopamine SPECT in Idiopathic Parkinsonian Diseases: A Follow-Up Study

Table 6

DAT and IBZM SPECT uptake in HC, PD, MSA, and PSP by region and SPECT timepoint.

(a)  

Baseline

HC; DAT 𝑛=14; IBZM 𝑛=14

PD; DAT 𝑛=29; IBZM 𝑛=29

MSA; DAT 𝑛=7; IBZM 𝑛=6

PSP; DAT 𝑛=13; IBZM 𝑛=12

Mann-Whitney U test

Mean

95% CI

Mean

95% CI

PD; versus HC

Mean

95% CI

MSA; versus HC

Mean

95% CI

PSP; versus HC

PD; versus MSA

PD; versus PSP

MSA; versus PSP

P *

P *

P *

P

P

P

Caudate DAT

4.47

4.14–4.80

3.18

2.94–3.42

<0.001

3.19

2.43–3.95

<0.001

2.83

2.50–3.15

<0.001

ns

ns

(0.075)

Putamen DAT

4.09

3.83–4.36

2.47

2.32–2.63

<0.001

2.74

2.16–3.31

<0.001

2.31

2.01–2.61

<0.001

ns

ns

(0.075)

Striate DAT

4.27

3.98–4.56

2.80

2.61–2.98

<0.001

2.95

2.31–3.59

<0.001

2.55

2.25–2.85

<0.001

ns

ns

(0.063)

Striate IBZM

1.82

1.74–1.91

1.79

1.73–1.85

1.00

1.84

1.66–2.03

1.00

1.79

1.70–1.88

1.00

ns

ns

ns

(b)  

Year 1
	PD; DAT 𝑛=29; IBZM 𝑛=29		MSA; DAT 𝑛=8; IBZM 𝑛=8		PSP; DAT 𝑛=12; IBZM 𝑛=10		Mann-Whitney U test
	Mean	95% CI	Mean	95% CI	Mean	95% CI	PD; versus MSA	PD; versus PSP	MSA; versus PSP
							P	P	𝑃
Caudate DAT	2.96	2.70–3.22	3.58	3.13–4.02	2.78	2.43–3.13	0.024	ns	0.007
Putamen DAT	2.28	2.13–2.43	2.56	2.25–2.87	2.17	1.89–2.46	(0.060)	ns	0.025
Striate DAT	2.59	2.40–2.79	3.02	2.67–3.38	2.45	2.15–2.76	0.029	ns	0.014
Striate IBZM	1.73	1.67–1.78	1.88	1.71–2.05	1.64	1.49–1.78	(0.051)	ns	0.026

(c)  

Year 3

HC; DAT 𝑛=16; IBZM 𝑛=16

PD; DAT 𝑛=22; IBZM 𝑛=17

MSA; DAT 𝑛=7; IBZM 𝑛=5

PSP; DAT 𝑛=3; IBZM 𝑛=5

Mann-Whitney U test

Mean

95% CI

Mean

95% CI

PD; versus HC

Mean

95% CI

MSA; versus HC

Mean

95% CI

PSP; versus HC

PD; versus MSA

PD; versus PSP

MSA; versus PSP

P *

P *

P *

P

P

P

Caudate DAT

4.35

4.06–4.63

2.83

2.55–3.12

<0.001

2.70

2.28–3.12

<0.001

2.38

1.80–2.96

<0.001

ns

ns

ns

Putamen DAT

3.96

3.71–4.21

2.13

1.97–2.30

<0.001

2.03

1.80–2.26

<0.001

1.92

1.50–2.34

<0.001

ns

ns

ns

Striate DAT

4.14

3.88–4.40

2.45

2.24–2.67

<0.001

2.33

2.03–2.63

<0.001

2.12

1.64–2.61

<0.001

ns

ns

ns

Striate IBZM

1.70

1.65–1.75

1.66

1.61–1.72

1.0

1.92

1.71–2.13

0.003

1.70

1.57–1.83

1.00

0.002

ns

0.016

Left and right uptake ratios are averaged.*One way ANOVA, Bonferroni post-hoc test P value. 95% CI: 95% confidence interval.