Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies

Table 2

Apparent permeability (𝑃_app) of different samples of DTX: free DTX, F-DTX, and DTX-loaded NPs (𝑛=3; data are showed as mean ± SD); the difference 𝑃<0.05 is considered as significant.

Test compound	Average 𝑃app^∗ (×10^−6 cm/s)
DTX	0.08 ± 0.14
F-DTX	0.38 ± 0.05
Ch50-GSH-DTX NPs	2.14 ± 0.22
Ch20-GSH-DTX NPs	2.43 ± 0.38

^∗𝑃_app: apparent permeability.