Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies

Table 3

Pharmacokinetics parameters in rats after i.v. administration of F-DTX and oral administration of F-DTX and Ch20-GSH-DTX NPs at the same 10 mg/kg drug dose.

PK Parameters	F-DTX (IV)	F-DTX (oral)	Ch20-GSH NPs (oral)
𝑇max (h)	0.5	2	5
𝐶max (ng/mL)	14,744 ± 2,354	456 ± 54.1	341 ± 47.5
AUC0--∞ (h⋅ng/mL)	65,245 ± 4,545	4,243 ± 207	44,998 ± 3,534
𝑇1/2 (h)	2.7 ± 0.6	11.7 ± 1.45	102.5 ± 12.6
MRT (h)	3.2 ± 0.3	15.7 ± 1.6	144.0 ± 10.7
Absolute bioavailability	—	6.5%	—
Relative bioavailability	—	—	68.9%