Human Mesenchymal Stem Cells Provide Protection against Radiation-Induced Liver Injury by Antioxidative Process, Vasculature Protection, Hepatocyte Differentiation, and Trophic Effects
Expression of SDF1α and mir-27b in liver and CXCR4 in implanted hMSCs. (a) At 3 and 7 days after irradiation, the level of SDF1 expression was significantly higher () in liver engrafted with hMSCs (white histogram) compared to unimplanted liver (grey histogram). At 15 days, the comparison was not possible because all the livers tested contained hMSCs. (b) The level of CXCR4 in hMSCs increased in vivo during the first days after injection and then decreased after 15 days. (c) The level of mir-27b in the liver of mice engrafted with hMSCs is less elevated than in liver ungrafted (Figure 4(c)). The level of mir-27b is more elevated in liver of mice ungrafted in comparison with liver containing hMSCs. The significance for all analyses was set at (**) and (***) and nonsignificance was noted as ns. Each group consisted of 5 animals ().
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