The Effect of Msh2 Knockdown on Toxicity Induced by tert-Butyl-hydroperoxide, Potassium Bromate, and Hydrogen Peroxide in Base Excision Repair Proficient and Deficient Cells
Figure 4
MTT and clonogenic survival curves for KBrO3 treatment of Nth1 +/+ and Nth1 −/− MEFs with and without reduced Msh2 expression. MTT (a) and clonogenic survival (b) curves for Nth1 +/+ + pshRNAMsh2283, clone 2 (88% Msh2 gene silencing; black square), and Nth1 +/+ + pshRNA empty (grey square) treated with KBrO3. MTT (c) and clonogenic survival (d) curves for Nth1 −/− + pshRNAMsh2283, clone 1 (85% Msh2 gene silencing; solid square), or Nth1 −/− + pshRNA empty (grey square) treated with KBrO3.
