Difference of Morphology and Immunophenotype between Central and Peripheral Squamous Cell Carcinomas of the Lung
Figure 2
Histologic and immunohistochemical features of squamous cell carcinoma. (a) The alveolar filling pattern showing a characteristic growth of filling up the alveolar space without destruction of the alveolar network (arrowhead). (b) Histology of the infiltrating pattern. The tumor forms irregular shaped nests and is intermingled with an extensive stroma. (c) Emphysema around the tumor is seen in the majority of peripheral squamous cell carcinomas (SqCCs). (d) Scanning magnification of tissue microarray holding triplicated 43 SqCC cases (SqCC cocktail antibody staining). (e) CK7 staining shows positive for entrapped pneumocytes. (f) Most of SqCC cases were positive for p63 (nuclear) and CK14 (cytoplasmic). Diameter of all cores is 0.6 mm.
