Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013, Article ID 162724, 7 pages
http://dx.doi.org/10.1155/2013/162724
Research Article

Antihyperglycemic Effect of Ginkgo biloba Extract in Streptozotocin-Induced Diabetes in Rats

1Department of Transfusion, The First Hospital of China Medical University, North Nanjing Street No. 155, Shenyang 110001, China
2High Vocational Technological College, China Medical University, Shenyang 11001, China
3Department of Clinical Laboratory, No. 202 Hospital, Shenyang 110003, China

Received 6 August 2012; Revised 7 November 2012; Accepted 8 November 2012

Academic Editor: Fabio Ferreira Perazzo

Copyright © 2013 Daye Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [42 citations]

The following is the list of published articles that have cited the current article.

  • Bambang Setiawan, Nia Kania, Dian Nugrahenny, Nurdiana Nurdiana, and Moch. Aris Widodo, “Subchronic inhalation of particulate matter 10 coal dust induces atherosclerosis in the aorta of diabetic and nondiabetic rats,” Biomarkers and Genomic Medicine, 2014. View at Publisher · View at Google Scholar
  • Kahkashan Rashid, and Parames C. Sil, “Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats,” Toxicology and Applied Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Khaled Mohamed Mohamed Koriem, “Antihyperlipidemic activity of the medicinal plants among Kadazan and Dusun communities in Sabah, Malaysia: a review,” Asian Pacific Journal of Tropical Biomedicine, vol. 4, no. 10, pp. 768–779, 2014. View at Publisher · View at Google Scholar
  • Hong-Ping Guan, and Guoxun Chen, “Factors Affecting Insulin-Regulated Hepatic Gene Expression,” Glucose Homeostatis and the Pathogenesis of Diabetes Mellitus, vol. 121, pp. 165–215, 2014. View at Publisher · View at Google Scholar
  • Sanro Tachibana, and Agus Sukito, “Potent α-glucosidase inhibitors isolated from Ginkgo biloba leaves,” Pakistan Journal of Biological Sciences, vol. 17, no. 11, pp. 1170–1178, 2014. View at Publisher · View at Google Scholar
  • Rajendran Petchi, Chockalingam Vijaya, and Subramani Parasuraman, “Antidiabetic activity of polyherbal formulation in streptozotocin- Nicotinamide induced diabetic wistar rats,” Journal of Traditional and Complementary Medicine, vol. 4, no. 2, pp. 108–117, 2014. View at Publisher · View at Google Scholar
  • Ying Li, Yin-Jie Li, Jing-Ying Qiu, Ting-Ting Bian, Dong-Zhi Yang, Dao-Quan Tang, Zheng Li, Xiao-Xiao Zheng, Feng-Lei Gao, and Yan-Yan Yu, “Screening for potential bioactive components in Ginkgo biloba extract by the rat renal tubular epithelial cell extraction and LC-MS/MS,” Combinatorial Chemistry and High Throughput Screening, vol. 18, no. 5, pp. 514–523, 2015. View at Publisher · View at Google Scholar
  • Sherien Kamal Hassan, Nermin Mohammed El-Sammad, Amria Mamdouh Mousa, Maha Hashim Mohammed, Abd el Razik Hussein Farrag, Amani Nassir Eldin Hashim, Victoria Werner, Ulrike Lindequist, and Mahmoud Abd El-Moein Nawwar, “Hypoglycemic and antioxidant activities of Caesalpinia ferrea Martius leaf extract in streptozotocin-induced diabetic rats,” Asian Pacific Journal of Tropical Biomedicine, vol. 5, no. 6, pp. 462–471, 2015. View at Publisher · View at Google Scholar
  • Bhesh Raj Sharma, and Dong Young Rhyu, “ Lespedeza davurica (Lax.) Schindl. Extract Protects against Cytokine-Induced β -Cell Damage and Streptozotocin-Induced Diabetes ,” BioMed Research International, vol. 2015, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Sze Han Ng, Mohd Shazwan Mohd Zain, Fatariah Zakaria, Wan Rosli Wan Ishak, and Wan Amir Nizam Wan Ahmad, “ Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats ,” BioMed Research International, vol. 2015, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Snehal Nitin Mestry, Jayesh Bachu Dhodi, Sangita Balbhim Kumbhar, and Archana Ramesh Juvekar, “Attenuation of diabetic nephropathy in streptozotocin-induced diabetic rats by Punica granatum Linn. leaves extract,” Journal of Traditional and Complementary Medicine, 2016. View at Publisher · View at Google Scholar
  • Özlem ÖZmen, and Senay Topsakal, “Insan Ve Hayvanlarda Diabetes Mellitus,” Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi, vol. 1, no. 1, pp. 47–47, 2016. View at Publisher · View at Google Scholar
  • Mohammad Raish, Ajaz Ahmad, Basit L. Jan, Khalid M. Alkharfy, Mushtaq Ahmad Ansari, Kazi Mohsin, Fahad al Jenoobi, and Abdullah Al-Mohizea, “Momordica charantia polysaccharides mitigate the progression of STZ induced diabetic nephropathy in rats,” International Journal of Biological Macromolecules, 2016. View at Publisher · View at Google Scholar
  • Tarek K. Motawi, Hebatallah A. Darwish, Manal A. Hamed, Nagy S. El-Rigal, and Asmaa F. Aboul Naser, “A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats,” Molecular Neurobiology, 2016. View at Publisher · View at Google Scholar
  • Nor Adlin Yusoff, Dwi Rita Anggraini, Mohd Zaini Asmawi, Vuanghao Lim, Bassel Al-Hindi, Khairul Niza Abdul Razak, Tri Widyawati, and Mariam Ahmad, “Nypa fruticans wurmb. Vinegar’s aqueous extract stimulates insulin secretion and exerts hepatoprotective effect on STZ-induced diabetic rats,” Nutrients, vol. 9, no. 9, 2017. View at Publisher · View at Google Scholar
  • Shiv Kumar, Vikram Patial, Sourabh Soni, Supriya Sharma, Kunal Pratap, Dinesh Kumar, and Yogendra Padwad, “Picrorhiza kurroa Enhances β-Cell Mass Proliferation and Insulin Secretion in Streptozotocin Evoked β-Cell Damage in Rats,” Frontiers in Pharmacology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Snehal Nitin Mestry, and Archana Ramesh Juvekar, “Aldose reductase inhibitory potential and anti-cataract activity of Punica granatum Linn. leaves against glucose-induced cataractogenesis in goat eye lens,” Oriental Pharmacy and Experimental Medicine, 2017. View at Publisher · View at Google Scholar
  • Navpreet Kaur, Lalit Kishore, and Randhir Singh, “Dillenia indica L. attenuates diabetic nephropathy via inhibition of advanced glycation end products accumulation in STZ-nicotinamide induced diabetic rats,” Journal of Traditional and Complementary Medicine, 2017. View at Publisher · View at Google Scholar
  • Tarek K. Motawi, Hebatallah A. Darwish, Manal A. Hamed, Nagy S. El-Rigal, and Asmaa F. Aboul Naser, “Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model,” Metabolic Brain Disease, 2017. View at Publisher · View at Google Scholar
  • Yue Liub, Keji Chen, and Jinfan Tian, “Ginkgo biloba extract in vascular protection: Molecular mechanisms and clinical applications,” Current Vascular Pharmacology, vol. 15, no. 6, pp. 532–548, 2017. View at Publisher · View at Google Scholar
  • Selcen Cakir, Meryem Eren, Meryem Senturk, and Zeynep Soyer Sarica, “The Effect of Boron on Some Biochemical Parameters in Experimental Diabetic Rats,” Biological Trace Element Research, 2017. View at Publisher · View at Google Scholar
  • Akram Ahangarpour, Majid Junghani, Reza Absari, Mehdi Khoogar, Ehsan Ghaedi, and Hamid Heidari, “Effects of hydroalcoholic extract of Rhus coriaria seed on glucose and insulin related biomarkers, lipid profile, and hepatic enzymes in nicotinamide-streptozotocin-induced type II diabetic male mice,” Research in Pharmaceutical Sciences, vol. 12, no. 5, pp. 416–424, 2017. View at Publisher · View at Google Scholar
  • Diaaeldin Mohamed Abdelkawi Elimam, Ahmed Salah uddin Ibrahim, Gregory Ing Liou, and Farid Abd-Elrehim Abd-elaziz Badria, “Olive and ginkgo extracts as potential cataract therapy with differential inhibitory activity on aldose reductase,” Drug Discoveries & Therapeutics, 2017. View at Publisher · View at Google Scholar
  • Jinfan Tian, Yanfei Liu, Yue Liu, Keji Chen, and Shuzheng Lyu, “Cellular and Molecular Mechanisms of Diabetic Atherosclerosis: Herbal Medicines as a Potential Therapeutic Approach,” Oxidative Medicine and Cellular Longevity, vol. 2017, pp. 1–16, 2017. View at Publisher · View at Google Scholar
  • F. Mayyas, “Cardiac effects of cigarette tobacco smoking in rat model of diabetes,” Life Sciences, 2018. View at Publisher · View at Google Scholar
  • Olorunfemi Raphael Molehin, Omotade Ibidun Oloyede, and Stephen Adeniyi Adefegha, “ Streptozotocin-induced diabetes in rats: effects of White Butterfly ( Clerodendrum volubile) leaves on blood glucose levels, lipid profile and antioxidant status ,” Toxicology Mechanisms and Methods, pp. 1–14, 2018. View at Publisher · View at Google Scholar
  • Abbas Alimoradian, Saeed Ghasemi, Mohammad Zahiri, Amir Hossein Saeedi, Hossein Miladi, and Mehdi Sadegh, “Investigation of the effect of Ginkgo biloba leaf extract on spatial memory impairment and hippocampal neuronal loss caused by diabetes induced by streptozotocin in rats,” Scientific Journal of Kurdistan University of Medical Sciences, vol. 23, no. 2, pp. 114–124, 2018. View at Publisher · View at Google Scholar
  • Saad Abdulrahman Hussain, Taha Othman Mahwi, Zheen Aorahman Ahmed, Abdullah Rasedee, Tavga Ahmed Aziz, and Heshu Sulaiman Rahman, “The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: A double-blind, randomized, placebo-controlled trial,” Drug Design, Development and Therapy, vol. 12, pp. 735–742, 2018. View at Publisher · View at Google Scholar
  • Ling Zhang, Qianqian Qin, Manni Liu, Xiangling Zhang, Fang He, and Guoqing Wang, “Akkermansia muciniphila can reduce the damage of gluco/lipotoxicity, oxidative stress and inflammation, and normalize intestine microbiota in streptozotocin-induced diabetic rats,” Pathogens and Disease, vol. 76, no. 4, 2018. View at Publisher · View at Google Scholar
  • F. Mayyas, R. Jaradat, and K.H. Alzoubi, “Cardiac effects of fish oil in a rat model of streptozotocin-induced diabetes,” Nutrition, Metabolism and Cardiovascular Diseases, 2018. View at Publisher · View at Google Scholar
  • Lei Zhang, Jiangang Liu, and Tao Geng, “Ginkgetin aglycone attenuates the apoptosis and inflammation response through nuclear factor-kB signaling pathway in ischemic-reperfusion injury,” Journal of Cellular Biochemistry, 2018. View at Publisher · View at Google Scholar
  • H.S. Nandini, and Prakash Ramachandra Naik, “Antidiabetic, antihyperlipidemic and antioxidant effect of Vincamine, in streptozotocin-induced diabetic rats,” European Journal of Pharmacology, 2018. View at Publisher · View at Google Scholar
  • Satirah Zainalabidin, Siti Balkis Budin, Nur Liyana Mohammed Yusof, Nur Najmi Mohamad Anuar, and Nur Afizah Yusoff, “Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant,” Journal of Applied Pharmaceutical Science, vol. 8, no. 1, pp. 108–114, 2018. View at Publisher · View at Google Scholar
  • Jinfan Tian, Yanfei Liu, Yue Liu, Keji Chen, and Shuzheng Lyu, “ Ginkgo biloba Leaf Extract Protects against Myocardial Injury via Attenuation of Endoplasmic Reticulum Stress in Streptozotocin-Induced Diabetic ApoE −/− Mice ,” Oxidative Medicine and Cellular Longevity, vol. 2018, pp. 1–13, 2018. View at Publisher · View at Google Scholar
  • Tavga Ahmed Aziz, Saad Abdulrahman Hussain, Taha Othman Mahwi, and Zheen Aorahman Ahmed, “Efficacy and safety of Ginkgo biloba extract as an “add-on” treatment to metformin for patients with metabolic syndrome: A pilot clinical study,” Therapeutics and Clinical Risk Management, vol. 14, pp. 1219–1226, 2018. View at Publisher · View at Google Scholar
  • Kamesh Venkatakrishnan, Hui-Fang Chiu, and Chin-Kun Wang, “Popular functional foods and herbs for the management of type-2-diabetes mellitus: A comprehensive review with special reference to clinical trials and its proposed mechanism,” Journal of Functional Foods, vol. 57, pp. 425–438, 2019. View at Publisher · View at Google Scholar
  • Hossam Ebaid, Samir A. E. Bashandy, Ibrahim M. Alhazza, Iftekhar Hassan, and Jameel Al-Tamimi, “ Efficacy of a Methanolic Extract of Adansonia digitata Leaf in Alleviating Hyperglycemia, Hyperlipidemia, and Oxidative Stress of Diabetic Rats ,” BioMed Research International, vol. 2019, pp. 1–10, 2019. View at Publisher · View at Google Scholar
  • Jinfan Tian, Mohammad Sharif Popal, Yanfei Liu, Rui Gao, Shuzheng Lyu, Keji Chen, and Yue Liu, “Ginkgo Biloba Leaf Extract Attenuates Atherosclerosis in Streptozotocin-Induced Diabetic ApoE-/- Mice by Inhibiting Endoplasmic Reticulum Stress via Restoration of Autophagy through the mTOR Signaling Pathway,” Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1–19, 2019. View at Publisher · View at Google Scholar
  • Ajaz Ahmad, Rao Muzaffar A. Khan, Khalid M. Alkharfy, Mohammad Raish, Fahad I. Al-Jenoobi, and Abdullah M. Al-Mohizea, “Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model,” Natural Product Communications, vol. 10, no. 8, pp. 1934578X1501000, 2019. View at Publisher · View at Google Scholar
  • Daklallah A. Almalki, Sameera A. Alghamdi, and Atef M. Al-Attar, “Comparative Study on the Influence of Some Medicinal Plants on Diabetes Induced by Streptozotocin in Male Rats,” BioMed Research International, vol. 2019, pp. 1–11, 2019. View at Publisher · View at Google Scholar
  • Hanan H. Ahmed, Fatma M. Taha, Heba S. Omar, Heba M. Elwi, and Marwa Abdelnasser, “Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy,” Molecular and Cellular Biochemistry, 2019. View at Publisher · View at Google Scholar
  • Yong Chen, Kaikai Yu, Yudong Hu, and Yanhua Chang, “Ginkgo biloba extract protects mesenteric arterioles of old rats via improving vessel elasticity through Akt/FoxO3a signaling pathway,” Annals of Vascular Surgery, 2019. View at Publisher · View at Google Scholar