Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013, Article ID 162724, 7 pages
http://dx.doi.org/10.1155/2013/162724
Research Article

Antihyperglycemic Effect of Ginkgo biloba Extract in Streptozotocin-Induced Diabetes in Rats

1Department of Transfusion, The First Hospital of China Medical University, North Nanjing Street No. 155, Shenyang 110001, China
2High Vocational Technological College, China Medical University, Shenyang 11001, China
3Department of Clinical Laboratory, No. 202 Hospital, Shenyang 110003, China

Received 6 August 2012; Revised 7 November 2012; Accepted 8 November 2012

Academic Editor: Fabio Ferreira Perazzo

Copyright © 2013 Daye Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. R. Whiting, L. Guariguata, C. Weil, and J. Shaw, “IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030,” Diabetes Research and Clinical Practice, vol. 94, pp. 311–321, 2011. View at Google Scholar
  2. B. S. Nayak and L. Roberts, “Relationship between inflammatory markers, metabolic and anthropometric variables in the Caribbean type 2 diabetic patients with and without microvascular complications,” Journal of Inflammation, vol. 3, article no. 17, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Pari and R. Saravanan, “Antidiabetic effect of diasulin, a herbal drug, on blood glucose, plasma insulin and hepatic enzymes of glucose mretabolism hyperglycaemic rats,” Diabetes, Obesity and Metabolism, vol. 6, no. 4, pp. 286–292, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. O. Savu, C. Ionescu-Tirgoviste, V. Atanasiu, L. Gaman, R. Papacocea, and I. Stoian, “Increase in total antioxidant capacity of plasma despite high levels of oxidative stress in uncomplicated type 2 diabetes mellitus,” The Journal of International Medical, vol. 40, pp. 709–716, 2012. View at Google Scholar
  5. F. Giacco and M. Brownlee, “Oxidative stress and diabetic complications,” Circulation Research, vol. 107, no. 9, pp. 1058–1070, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. M. M. Ali and F. G. Agha, “Amelioration of streptozotocin-induced diabetes mellitus, oxidative stress and dyslipidemia in rats by tomato extract lycopene,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 69, no. 3, pp. 371–379, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. S. M. Son, “Reactive oxygen and nitrogen species in pathogenesis of vascular complications of diabetes,” Journal of Diabetes & Metabolism, vol. 36, pp. 190–198, 2012. View at Google Scholar
  8. A. N. Shafik, “Effects of topiramate on diabetes mellitus induced by streptozotocin in rats,” European Journal of Pharmacology, vol. 684, pp. 161–167, 2012. View at Google Scholar
  9. F. Hu, W. Zhu, M. Chen, Q. Shou, and Y. Li, “Biological activities of Chinese propolis and Brazilian propolis on streptozotocin-induced type 1 diabetes mellitus in rats,” Evidence-based Complementary and Alternative Medicine, vol. 2011, Article ID 468529, 8 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. I. Ilieva, K. Ohgami, K. Shiratori et al., “The effects of Ginkgo biloba extract on lipopolysaccharide-induced inflammation in vitro and in vivo,” Experimental Eye Research, vol. 79, no. 2, pp. 181–187, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Louajri, S. Harraga, V. Godot, G. Toubin, J. P. Kantelip, and P. Magninc, “The effect of Ginkgo biloba extract on free radical production in hypoxic rats,” Biological and Pharmaceutical Bulletin, vol. 24, no. 6, pp. 710–712, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Ashok Shenoy, S. N. Somayaji, and K. L. Bairy, “Evaluation of hepatoprotective activity of Ginkgo biloba in rats,” Indian Journal of Physiology and Pharmacology, vol. 46, no. 2, pp. 167–174, 2002. View at Google Scholar · View at Scopus
  13. A. Eckert, U. Keil, S. Kressmann et al., “Effects of EGb 761® Ginkgo biloba extract on mitochondrial function and oxidative stress,” Pharmacopsychiatry, vol. 36, supplement 1, pp. S15–S23, 2003. View at Google Scholar · View at Scopus
  14. S. K. Jain, S. N. Levine, J. Duett, and B. Hollier, “Elevated lipid peroxidation levels in red blood cells of streptozotocin-treated diabetics rats,” Metabolism: Clinical and Experimental, vol. 39, no. 9, pp. 971–975, 1990. View at Publisher · View at Google Scholar · View at Scopus
  15. S. B. Biddinger and C. R. Kahn, “From mice to men: insights into the insulin resistance syndromes,” Annual Review of Physiology, vol. 68, pp. 123–158, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. F. J. Alarcon-Aguilara, R. Roman-Ramos, S. Perez-Gutierrez, A. Aguilar-Contreras, C. C. Contreras-Weber, and J. L. Flores-Saenz, “Study of the anti-hyperglycemic effect of plants used as antidiabetics,” Journal of Ethnopharmacology, vol. 61, no. 2, pp. 101–110, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Shi, F. Wu, and J. Xu, “H2O2 and PAF mediate Aβ1-42-induced Ca2+ dyshomeostasis that is blocked by EGb761,” Neurochemistry International, vol. 56, no. 8, pp. 893–905, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. H. Niu, X. Y. Yang, and W. S. Bao, “Protective effects of Ginkgo biloba extract on cultured rat cardiomyocytes damaged by H2O2,” Acta Pharmacologica Sinica, vol. 20, no. 7, pp. 635–638, 1999. View at Google Scholar · View at Scopus
  19. S. K. Swanston-Flatt, C. Day, C. J. Bailey, and P. R. Flatt, “Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice,” Diabetologia, vol. 33, no. 8, pp. 462–464, 1990. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Kavalali, H. Tuncel, S. Göksel, and H. H. Hatemi, “Hypoglycemic activity of Urtica pilulifera in streptozotocin-diabetic rats,” Journal of Ethnopharmacology, vol. 84, no. 2-3, pp. 241–245, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. G. B. Kudolo, “The effect of 3-month ingestion of Ginkgo biloba extract on pancreatic β-cell function in response to glucose loading in normal glucose tolerant individuals,” Journal of Clinical Pharmacology, vol. 40, no. 6, pp. 647–654, 2000. View at Google Scholar · View at Scopus
  22. G. B. Kudolo, “The effect of 3-month ingestion of Ginkgo biloba extract (EGb 761) on pancreatic β-cell function in response to glucose loading in individuals with non-insulin-dependent diabetes mellitus,” Journal of Clinical Pharmacology, vol. 41, no. 6, pp. 600–611, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Zhou, Q. Meng, T. Qian, and Z. Yang, “Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells,” Journal of Natural Medicines, vol. 65, no. 1, pp. 50–56, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. Q. Zhang, G. J. Wang, J. Y. A et al., “Application of GC/MS-based metabonomic profiling in studying the lipid-regulating effects of Ginkgo biloba extract on diet-induced hyperlipidemia in rats,” Acta Pharmacologica Sinica, vol. 30, no. 12, pp. 1674–1687, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. S. De Sereday, C. Gonzalez, D. Giorgini et al., “Prevalence of diabetes, obesity, hypertension and hyperlipidemia in the central area of Argentina,” Diabetes and Metabolism, vol. 30, no. 4, pp. 335–339, 2004. View at Google Scholar · View at Scopus
  26. S. B. Sharma, A. Nasir, K. M. Prabhu, P. S. Murthy, and G. Dev, “Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits,” Journal of Ethnopharmacology, vol. 85, no. 2-3, pp. 201–206, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. Z. X. Yao, Z. Han, K. Drieu, and V. Papadopoulos, “Ginkgo biloba extract (Egb 761) inhibits β-amyloid production by lowering free cholesterol levels,” Journal of Nutritional Biochemistry, vol. 15, no. 12, pp. 749–756, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Yao, F. Song, K. Li et al., “Ginkgo biloba extract prevents ethanol induced dyslipidemia,” American Journal of Chinese Medicine, vol. 35, no. 4, pp. 643–652, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. B. Ramesh and D. Saralakumari, “Antihyperglycemic, hypolipidemic and antioxidant activities of ethanolic extract of Commiphora mukul gum resin in fructose-fed male Wistar rats,” Journal of Physiology and Biochemistry, vol. 68, no. 4, pp. 573–582, 2012. View at Google Scholar
  30. M. S. Balasubashini, R. Rukkumani, P. Viswanathan, and V. P. Menon, “Ferulic acid alleviates lipid peroxidation in diabetic rats,” Phytotherapy Research, vol. 18, no. 4, pp. 310–314, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. H. F. Al-Azzawie and M. S. S. Alhamdani, “Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits,” Life Sciences, vol. 78, no. 12, pp. 1371–1377, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. D. Cheng and H. Kong, “The effect of lycium barbarum polysaccharide on alcohol-induced oxidative stress in rats,” Molecules, vol. 16, no. 3, pp. 2542–2550, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. R. P. Robertson, Y. Tanaka, H. Takahashi, P. O. T. Tran, and J. S. Harmon, “Prevention of oxidative stress by adenoviral overexpression of glutathione-related enzymes in pancreatic islets,” Annals of the New York Academy of Sciences, vol. 1043, pp. 513–520, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. S. R. Naik, V. W. Pilgaonkar, and V. S. Panda, “Evaluation of antioxidant activity of Ginkgo biloba phytosomes in rat brain,” Phytotherapy Research, vol. 20, no. 11, pp. 1013–1016, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. H. Okur, M. Kucukaydin, K. Kose, O. Kontas, P. Dogan, and A. Kazez, “Hypoxia-induced necrotizing enterocolitis in the immature rat: the role of lipid peroxidation and management by vitamin E,” Journal of Pediatric Surgery, vol. 30, no. 10, pp. 1416–1419, 1995. View at Google Scholar · View at Scopus
  36. C. Kabaroglu, M. Akisu, S. Habif et al., “Effects of L-arginine and L-carnitine in hypoxia/reoxygenation-induced intestinal injury,” Pediatrics International, vol. 47, no. 1, pp. 10–14, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. U. Bicakci, B. Tander, E. Aritürk et al., “Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/reoxygenation induced intestinal injury in newborn rats,” Pediatric Surgery International, vol. 21, no. 10, pp. 800–805, 2005. View at Publisher · View at Google Scholar · View at Scopus