Research Article

Mutations in the embB Gene and Their Association with Ethambutol Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates from Poland

Table 1

Mutations detected in 50 MDR M. tuberculosis isolates under the study.

MutationaNo. (%) of isolates with detected mutation
NucleotideAmino acidEMB-resistant ( )EMB-susceptible ( )

A G (916)Met Val (306)4 (23.5)3 (9.1)
G A (918)Met Ile (306)3 (17.6)5 (15.1)
G C (918)Met Ile (306)1 (5.9)3 (9.1)
G C (1217)Gly Ala (406)4 (23.5)
T C (1238)*Leu Pro (413)1 (3)
A G (1490)Gln Arg (497)1 (3)
G C (1510)*Glu Gln (504)1 (3)
G A (918) and
A G (1519)*
Met Ile (306)
and Arg Gly (507)
1 (5.9)

Numbers in brackets indicate nucleotide positions and amino acid residue positions; *novel mutation.