Mutations in the embB Gene and Their Association with Ethambutol Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates from Poland
Table 1
Mutations detected in 50 MDR M. tuberculosis isolates under the study.
Mutationa
No. (%) of isolates with detected mutation
Nucleotide
Amino acid
EMB-resistant ()
EMB-susceptible ()
A G (916)
Met Val (306)
4 (23.5)
3 (9.1)
G A (918)
Met Ile (306)
3 (17.6)
5 (15.1)
G C (918)
Met Ile (306)
1 (5.9)
3 (9.1)
G C (1217)
Gly Ala (406)
4 (23.5)
—
T C (1238)*
Leu Pro (413)
—
1 (3)
A G (1490)
Gln Arg (497)
—
1 (3)
G C (1510)*
Glu Gln (504)
—
1 (3)
G A (918) and A G (1519)*
Met Ile (306) and Arg Gly (507)
1 (5.9)
—
Numbers in brackets indicate nucleotide positions and amino acid residue positions; *novel mutation.