Lifting the Silver Flakes: The Pathogenesis and Management of Chronic Plaque Psoriasis

Table 1

A summary of different subsets of T cells and the role of their respective cytokines in the pathogenesis of psoriasis. Figure adapted and modified from [28].

T cell			Role in the pathogenesis of psoriasis
Types	Subtypes	Cytokines produced	Keratinocytes hyperproliferation	Skin inflammation	Dendritic cell maturation	Immune response amplification
CD4^+	Th1	IFN-γ	•	•	•
	Th17	IL-17	•	•		•
		IL-21	•	•
		IL-22	•
		IL-6	•
	Th22	IL-22	•	•
	FoxP3^+Treg	IL-17	•	•		•
CD8^+		IL-17	•	•		•
		IL-22	•	•
		IFN-γ	•	•
		TNF-α	•		•
𝛾𝛿	Dermal	IL-17	•	•		•
		IL-22	•
		TNF-α	•		•
NK		IL-17	•	•		•