Computational Analysis of the Soluble Form of the Intracellular Chloride Ion Channel Protein CLIC1
Figure 1
Structure and dynamics of human CLIC1. (a) Ribbon representation of the human CLIC1 structure used in the simulations. GSH is shown in stick form. The foot loop (residues 147–164) was modeled using coordinates from nonliganded CLIC1 (PDB 1K0 M). Secondary structural elements discussed in the text are as indicated. Residues are shaded according to the combined fluctuations for slow modes 1–5 from the GNM analysis with white, low and black, high fluctuations. (b) Per residue plot of average of RMS fluctuations of C atoms from all simulations (black). The fluctuation profile predicted by GNM analysis for slow modes 1–5 is in grey. The GNM data are scaled linearly to fit the range of the MD data for the purposes of comparison.
