Computational Analysis of the Soluble Form of the Intracellular Chloride Ion Channel Protein CLIC1
Figure 6
Structure and dynamics of the foot loop. (a) Fluctuations of the foot loop. Per residue fluctuations of C atoms during the simulations: apo1, red; apo2, blue; cov1, green; cov2, yellow; ncv2, purple. Fluctuations taken over the final 20 ns of each simulation relative to the average structure over the same period for the respective simulation. (b) Conformational variability of the foot loop. Superimposed trajectory frames taken at 7.5 ns intervals, coloured according to the time: start (blue); end (red). (c) Electronegativity of the foot loop. Electrostatic potential around the structure of CLIC1 is depicted as a surface representing isovalues; potential of +1 is coloured blue and −1 red. The view is similar to that in Figure 1. Final frame from each simulation was analysed.
