A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis

Table 1

Correlation analyses of the change in peak vertical force measurement and magnetic resonance imaging over the different phases of functional impairment before (Baseline) and following cranial cruciate ligament transection in five dogs.

	Osteophytes	Joint effusion	Focal cartilage changes	BMLs		Meniscal tears	Cartilage volume loss
				T2w-FS	T1w-GRE
	Phase of functional impairment nadir
𝑟𝑠	−0.05	−0.26	−0.70	−0.70	−0.70	0.01	−0.40
𝑃	NS	NS	NS	NS	NS	NS	NS
	Phase of remission
𝑟𝑠	−0.90	−0.95	−0.97	−0.70	−0.99	0.79	0.60
𝑃	0.037	0.013	0.004	NS	<0.001	𝑃=0.1	𝑃=0.1

Nonsignificant at 5% level (NS).
Spearman coefficients (𝑟_𝑠).
Probability value (𝑃).
Bone marrow lesions (BMLs).
T1-weighted three-dimensional fast gradient recalled echo (T1w-GRE).
T2-weighted fast spin echo sequence with fat saturation (T2w-FS).
The changes in the phase of functional impairment nadir were calculated using week four values minus Baseline. The changes in the phase of remission were calculated using week 26 values minus week four.