Safety Assessment and Biological Effects of a New Cold Processed SilEmulsion for Dermatological Purpose

Table 5

Summary of the biological safety of the ingredients.

INCI name	Acute toxicity	Dermal irritation	Ocular irritation	Sensitization	Genotoxicity/; carcinogenicity	References
Bis-PEG/PPG-16/16 PEG/PPG-16/16 dimethicone (and) caprylic/capric triglyceride	n.a	n.a	n.a	n.a	n.a	—
PEG-20 glyceryl laurate	Rat (oral) LD50 > 48 mL/kg	Non irritant	Rabbit: non irritant	n.a	n.a	[15]
Isopropyl myristate	Rat (oral) LD50 > 5000 mg/kg	Rabbit (undiluted): mild irritant	Rabbit: minimally irritant	Guinea pig: nonsensitizer; Human: nonsensitizer	n.a	[16, 17]
C12-15 alkyl benzoate	Rat (oral) LD50 > 2000 mg/kg; Rabbit (dermal) LD50 > 2000 mg/kg	Rabbit: non irritant	Rabbit: non irritant	Guinea pig: non sensitizer	n.a	[18, 19]
Hidroxy propyl methyl cellulose	Oral LD50 > 10000 mg/kg	Can cause irritation	Can cause irritation	Guinea pig: non sensitizer	n.a	[12]
PVM/MA decadiene crosspolymer	Rat (oral) LD50 > 1500 mg/kg; Rat (oral), 1% in solution LD50 > 5000 mg/kg	Rabbit: slightly irritant	May cause irritation	Human patch test: non sensitizer; (2% gel)	In vitro gene mutation in bacteria: negative	[20]
Cetrimide	Rat (oral) LD50 > 400 < 600 mg/kg	Rabbit: irritant	Potent irritant	Sensitizer	Salmonella Typhimurium: negative	[21]
1,5-Pentanediol	Rat (oral) LD50 10000 mg/kg; Rabbit (dermal) LD50 > 19800 mg/kg	Rabbit: non irritant	Rabbit: non irritant	n.a	Ames test: negative	[22]