Gene Therapy and Cell-Based Therapies for Therapeutic Angiogenesis in Peripheral Artery Disease

Table 1

Clinical trials of gene therapy in peripheral artery diseases.

Authors	Year	Gene	Vector	Delivery route	𝑛	Reference number
Baumgartner et al.	1998	VEGF165	naked pDNA	IM	9	[4]
Isner et al.	1998	VEGF165	naked pDNA	IM	6	[5]
Rajagopalan et al.	2001	VEGF121	adenovirus	IM	5	[7]
Mäkinen et al.	2002	VEGF165	adenovirus, plasmid/liposome	IA	54	[6]
Comerota et al.	2002	FGF-1	naked pDNA	IA	51	[11]
Rajagopalan et al.	2003	VEGF121	adenovirus	IM	1 : 1 : 1 fashion to low dose, high dose, or placebo arms (35-36 patients in each group)	[9]
Kusumanto et al.	2006	VEGF165	naked pDNA	IM	54	[8]
Nikol et al.	2008	FGF-1	naked pDNA	IM	125	[12]
Shigematsu et al.	2010	HGF	naked pDNA	IM	44	[13]
Belch et al.	2011	FGF-1	naked pDNA	IM	525	[14]
Morishita et al.	2011	HGF	naked pDNA	IM	22	[15]

VEGF: vascular endothelial growth factor; FGF: fibroblast growth factor (FGF); HGF: hepatocyte growth factors.