Gene Therapy and Cell-Based Therapies for Therapeutic Angiogenesis in Peripheral Artery Disease

Table 2

Clinical trials of cell-based therapy in peripheral artery diseases.

Authors	Year	Cell	Delivery route	𝑛	Reference number
Tateishi-Yuyama et al.	2002	BMMNC or PBMNC	IM	45	[28]
Esato et al.	2002	BMC	IM	8	[29]
Huang et al.	2005	PBMNC	IM	28	[30]
Miyamoto et al.	2006	BMMNC	IM	8	[31]
Durdu et al.	2006	BMMNC	IM	28	[32]
Arai et al.	2006	G-CSF	SC	39	[33]
Huang et al.	2007	BMMNC or PBMNC	IM	150	[34]
Kawamoto et al.	2009	EPC	IM	17	[35]
Procházka et al.	2010	BMC	IM	96	[36]
Murphy et al.	2011	BMMNC	IM	29	[37]
Lu et al.	2011	BMMNC or BMMSC	IM	41	[38]
Walter et al.	2011	BMMNC	IA	40	[39]
Powell et al.	2012	Ixmyelocel-T	IM	72	[40]
Losordo et al.	2012	EPC	IM	28	[41]

PBMNC: peripheral blood mononuclear cells; BMC: bone marrow cell; BMMNC: bone marrow-derived mononuclear cell; BMMSC: bone marrow mesenchymal stem cell; G-CSF: granulocyte colony-stimulating factor; EPC: endothelial progenitor cell.