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BioMed Research International
Volume 2013, Article ID 186563, 6 pages
Review Article

Targeting Brain Metastases in Patients with Melanoma

Medical Oncology Department, Guy’s and St Thomas’ NHS Foundation Trust, UK

Received 26 September 2013; Revised 12 November 2013; Accepted 18 November 2013

Academic Editor: H. Peter Soyer

Copyright © 2013 Dionysis Papadatos-Pastos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Patients with brain metastases from malignant melanoma historically have a very poor outcome. Surgery and radiotherapy can be used, but for the majority of patients the disease will progress quickly. In the recent past, patients with brain metastases derived only minimal benefit from cytotoxic chemotherapy. Novel therapies that have been shown to be superior to chemotherapy in metastatic melanoma have made their way in clinic and data regarding their use in patients with treated or untreated brain metastases are encouraging. In this paper we describe the use of vemurafenib, dabrafenib, and ipilimumab in patients with melanoma disseminated to the brain in addition to other treatments currently in development.