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BioMed Research International
Volume 2013, Article ID 187254, 6 pages
http://dx.doi.org/10.1155/2013/187254
Clinical Study

Primary Immunodeficiency Diseases at Reference and High-Specialty Hospitals in the State of Guanajuato, Mexico

1Departamento de Inmunología, Hospital Regional de Alta Especialidad del Bajío, Boulevard Milenio 130 San Carlos La Roncha, 37660 León, GTO, Mexico
2Centro Médico Nacional del Bajío, IMSS, 37320 León, GTO, Mexico
3Departamento de Inmunoalergología Pediátrica, Hospital Ángeles-León, 37150 León, GTO, Mexico
4Hospital Regional de León ISSSTE, 37520 León, GTO, Mexico

Received 30 April 2013; Accepted 19 July 2013

Academic Editor: Anthony L. DeVico

Copyright © 2013 Eduardo Guaní-Guerra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. In general, primary immunodeficiency diseases (PIDs) are underdiagnosed in most countries. The objective of this study was to describe the frequency and clinical spectrum of PID in the most important tertiary hospitals in our region. Methods. An observational, cross-sectional, with retrospective chart, review study was conducted. A total of 26 patients were included and grouped according to the updated classification of PIDs. Results. PIDs spectra were as follows: predominantly antibody deficiency diseases were the most common category (65.38%), followed by other well-defined immunodeficiency syndromes (11.55%), congenital defects of phagocyte number and/or function (7.69%), complement deficiencies (3.85%), combined T- and B-cell immunodeficiencies (3.85%), and defects in innate immunity (3.85%). The mean time elapsed from the onset of symptoms to the reference and diagnosis by a tertiary hospital was of 4.65 ± 6.95 years. Conclusions. Predominant antibody deficiency disease was the most common group of PIDs, agreeing with international reports. Awareness of underdiagnosis by physicians is crucial for a prompt diagnosis and treatment, which in turn should improve the quality of life among patients with PIDs.