Reconstruction and Analysis of Human Kidney-Specific Metabolic Network Based on Omics Data
The functional characteristics of KS and HK genes in the kidney-specific metabolic model. (a) shows the distribution of predicted relative growth rates of HK and KS genes using both FBA (blue star) and linear MOMA (red circle) methods. The axis represents growth rate ratio between deletion strain to knockout strain, and the axis represents the 297 HK genes and 34 KS genes. (b) shows a typical example of effects of KS gene mutant strains on the network flexibility. In the mutant strain of Solute carrier family 7 member 9 (SLC7A9), the majority (99.51%) of the metabolic reactions do not change flux span compared to wild-type strain while 12 reactions have much higher () flux span.
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