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BioMed Research International
Volume 2013, Article ID 194371, 13 pages
http://dx.doi.org/10.1155/2013/194371
Research Article

The Pyridoxal 5′-Phosphate (PLP)-Dependent Enzyme Serine Palmitoyltransferase (SPT): Effects of the Small Subunits and Insights from Bacterial Mimics of Human hLCB2a HSAN1 Mutations

Ashley E. Beattie,1 Sita D. Gupta,2 Lenka Frankova,3 Agne Kazlauskaite,1 Jeffrey M. Harmon,4 Teresa M. Dunn,2 and Dominic J. Campopiano1

1EastChem School of Chemistry, The University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK
2Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20184-4779, USA
3The Edinburgh Cell Wall Group, Institute of Molecular Plant Sciences, School of Biological Sciences, The University of Edinburgh, Daniel Rutherford Building, Edinburgh EH9 3JH, UK
4Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20184-4779, USA

Received 12 June 2013; Accepted 22 July 2013

Academic Editor: Roberto Contestabile

Copyright © 2013 Ashley E. Beattie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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