Improving Drug Loading of Mucosal Solvent Cast Films Using a Combination of Hydrophilic Polymers with Amoxicillin and Paracetamol as Model Drugs
Table 1
(a) Optimised blank films prepared with different amounts of polymers and plasticiser and (b) films containing varying amounts of paracetamol and amoxicillin.
(a) Blank films
Mixture of polymers and plasticizer
Weight ratios
Total polymer weight (mg)
5 : 3 : 3
1100
SA : CMC : GLY
5 : 3 : 6
1400
5 : 2 : 3
1000
CAR : CMC : SA : GLY
2 : 2 : 2 : 3
900
CAR : SA : GLY
2 : 3 : 6
1100
CAR : CMC : GLY
1 : 2 : 3
600
(b) Drug loaded films
Formulation
Weight without drug (mg)
Weight of drug (mg)
Total dry weight (mg)
Drug loading (% of film dry weight)
Paracetamol
SA : CMC : GLY (5 : 3 : 3)
1100
100
1200
8.3
SA : CMC : GLY (5 : 3 : 3)
1100
150
1250
12.0
SA : CMC : GLY (5 : 2 : 3)
1000
150
1150
13.0
CAR : CMC : SA : GLY (2 : 2 : 2 : 3)
900
50
950
5.3
CAR : CMC : SA : GLY (2 : 2 : 2 : 3)
900
75
975
7.7
CAR : CMC : SA : GLY (2 : 2 : 2 : 3)
900
200
1100
18.2
CAR : CMC : GLY (1 : 2 : 3)
600
250
850
29.4
CAR : CMC : GLY (1 : 2 : 3)
600
300
900
33.3
CAR : CMC : GLY (1 : 2 : 3)€
600
400
1000
40.0
Amoxicillin
SA : CMC : GLY (5 : 3 : 6)
1400
250
1650
15.2
SA : CMC : GLY (5 : 3 : 6)
1400
300
1700
17.6
SA : CMC : GLY (5 : 3 : 6)
1400
350
1750
20.0
SA : CMC : GLY (5 : 3 : 6)
1400
400
1800
22.2
SA : CMC : GLY (5 : 3 : 6)*
1400
500
1900
26.3
CAR : SA : GLY (2 : 3 : 6)
1100
450
1550
29.0
CAR : CMC : GLY (1 : 2 : 3)
600
500
1100
45.5
€Optimised paracetamol loaded films selected for further characterization.
*Optimised amoxicillin loaded films selected for further characterisation.
