TNNT2 Gene Polymorphisms Are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in the Han Chinese Population

Table 2

Identified DNA variants and the Hardy-Weinberg equilibrium of 10 SNPs in the TNNT2 gene in the DCM patients and control subjects.


Markers	Location of nucleotide change	Amino acid change	Note	Obs HET	Expt HET	HWE (P)	MAF

rs7521796	Intron 201330019 A>G	Noncoding	Novel noncoding SNP	0.115	0.115	1	0.061
rs2275862	Intron 201330366 C>G	Non-coding	Novel non-coding SNP	0.329	0.319	0.7683	0.199
rs3729547	201334382 T>C	Synonymous Ile [I]	Reported synonymous	0.504	0.484	1	0.41
rs10800775	Intron 201336386 C>T	Non-coding	Novel non-coding SNP	0.474	0.448	0.771	0.339
rs1892028	Intron 201336641 A>G	Non-coding	Novel non-coding SNP	0.489	0.498	0.7396	0.47
rs3729843	Intron 201336984 G>A	Non-coding	Reported non-coding SNP	0.285	0.331	0.5949	0.21
rs3729842	Intron 201337170 C>T	Non-coding	Reported non-coding SNP	0.225	0.241	0.3594	0.14
rs12563114	Intron 201344908 C>T	Non-coding	Novel non-coding SNP	0.081	0.084	0.5638	0.044
rs12564445	Intron 201345487 G>A	Non-coding	Novel non-coding SNP	0.435	0.427	0.7891	0.309
rs4915232	5′ near gene 201347946 A>G	Non-coding	Novel non-coding SNP	0.535	0.499	0.7407	0.482

Note: Obs HET: observed heterozygosity, Expt HET: expected heterozygosity, HWE (P): P value from the Hardy-Weinberg equilibrium test, and MAF: minor allele frequency.

BioMed Research International

TNNT2 Gene Polymorphisms Are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in the Han Chinese Population

Table 2