TNNT2 Gene Polymorphisms Are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in the Han Chinese Population
Table 2
Identified DNA variants and the Hardy-Weinberg equilibrium of 10 SNPs in the TNNT2 gene in the DCM patients and control subjects.
Markers
Location of nucleotide change
Amino acid change
Note
Obs HET
Expt HET
HWE (P)
MAF
rs7521796
Intron 201330019 A>G
Noncoding
Novel noncoding SNP
0.115
0.115
1
0.061
rs2275862
Intron 201330366 C>G
Non-coding
Novel non-coding SNP
0.329
0.319
0.7683
0.199
rs3729547
201334382 T>C
Synonymous Ile [I]
Reported synonymous
0.504
0.484
1
0.41
rs10800775
Intron 201336386 C>T
Non-coding
Novel non-coding SNP
0.474
0.448
0.771
0.339
rs1892028
Intron 201336641 A>G
Non-coding
Novel non-coding SNP
0.489
0.498
0.7396
0.47
rs3729843
Intron 201336984 G>A
Non-coding
Reported non-coding SNP
0.285
0.331
0.5949
0.21
rs3729842
Intron 201337170 C>T
Non-coding
Reported non-coding SNP
0.225
0.241
0.3594
0.14
rs12563114
Intron 201344908 C>T
Non-coding
Novel non-coding SNP
0.081
0.084
0.5638
0.044
rs12564445
Intron 201345487 G>A
Non-coding
Novel non-coding SNP
0.435
0.427
0.7891
0.309
rs4915232
5′ near gene 201347946 A>G
Non-coding
Novel non-coding SNP
0.535
0.499
0.7407
0.482
Note: Obs HET: observed heterozygosity, Expt HET: expected heterozygosity, HWE (P): P value from the Hardy-Weinberg equilibrium test, and MAF: minor allele frequency.
