Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling

<table>Total metabolite changes induced by lisinopril treatment. Metabolite changes were calculated as the ratio of the mean of metabolite levels in individual rats in a treatment group relative to mean of metabolite levels in rats in a matched control group (time point, dose level, and sex); the significance level was 0.05.</table>

BioMed Research International

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Figure 5

Figure 5: Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling 