Research Article
Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling
Table 6
Summary of metabolite profiling and comparison with know toxicities.
| Drug | Target | Rat study standard findings | Human clinical findings | MMtox prediction |
| Captopril | Kidney | Yes | Yes | Yes (*) | Lisinopril | Kidney | Yes | Yes | Yes (*) | Cyclosporin A | Kidney | Yes | Yes | Yes | Doxorubicin | Kidney | Yes | Yes | Yes | Phenytoin | Kidney | No | No | No | Captopril | Liver | No | Yes | Yes | Cyclosporin A | Liver | Yes | Yes | Yes | Doxorubicin | Liver | Yes | Yes | Yes | Lisinopril | Liver | No | No | No | Phenytoin | Liver | No | Yes | Yes | Cyclosporin A | Anemia | Yes | Yes | Yes | Doxorubicin | Anemia | Yes | Yes | Yes | Captopril | Bone marrow | Yes | Yes | Yes | Lisinopril | Platelet | Yes | Yes | Yes |
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The treatments with these compounds were used to define some of the patterns for kidney toxicity.
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