Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro
Figure 1
Effect of Exogenous nucleotides on ethanol-induced developmental malformation on mouse embryos cultured in vitro. (a) Normal control; (b) ethanol control; (c) 0.16 mg/L; (d) 0.80 mg/L; (e) 4.00 mg/L; (f) 20.00 mg/L; (g) 100.00 mg/L. 1: fore brain; 2: midbrain; 3: hind brain; 4: branchial arch; 5: tail neural tube. Failure of neural folds to fuse in the midline in one or more regions of the forebrain, midbrain, and hindbrain was obvious in ethanol control, 0.16 mg/L nucleotides, and 0.80 mg/L nucleotides intervention groups. 4.00 mg/L nucleotides showed best protective effects. The morphology development became worse at doses above 4.00 mg/L.
