Induction of Mast-Cell Accumulation by Promutoxin, an Arg-49 Phospholipase A₂

Table 1

The influence of anti-inflammatory compounds on promutoxin- (5 μg) induced mast-cell accumulation in mouse peritoneum.

Compound injected	Number of mast cells; (×10^3)
Saline	14.6 (6.1–23)
Promutoxin	44.6 (21.4–60.8)
Ginkgolide B 5 mg·kg^−1	26.2 (9.1–41)
Ginkgolide B 5 mg·kg^−1 + promutoxin	28.6 (13–50.2)*
Cyproheptadine 2 mg·kg^−1	6.2 (1.5–17.2)
Cyproheptadine 2 mg·kg^−1 + promutoxin	12.8 (4.2–22.2)*
Terfenadine 2 mg·kg^−1	11.0 (5.8–20)
Terfenadine 2 mg·kg^−1 + promutoxin	3.3 (1.6–6.5)*
Quinacrine 10 mg·kg^−1	11.5 (5.9–18.1)
Quinacrine 10 mg·kg^−1 + promutoxin	36.8 (25.3–49.3)

The values shown are medians (range) for six separate experiments. Compounds were injected into the mouse peritoneum for 6 h before peritoneal lavage fluid was collected. ^*𝑃<0.05 compared with the response to promutoxin alone.