Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors

Table 3

Melanin production and cytotoxicity.

Entry	Compound	Melanin production Inhibition (%)	Cytotoxicity cell viability (%)
1	5a	42.14±0.75	82.15±3.55
2	5b	40.98±4.33	80.06±1.89
3	5c	35.93±3.11	83.15±2.22
4	5d	37.50±4.09	84.67±5.38
5	5e	36.84±1.44	81.91±1.08
6	5f	34.74±2.22	80.59±2.65
7	Kojic acid^a	17.28±1.29^b	81.68±1.23^b

aStandard inhibitors of the enzyme tyrosinase.
bTested at 200 µg/mL.