Modification of a Rodent Hindlimb Model of Secondary Lymphedema: Surgical Radicality versus Radiotherapeutic Ablation
In vivo measurement of hindlimb volume and lymphatic flow. (a) Volume measurements of hindlimbs at different time intervals and compared against the normal left hindlimb. There is an overall increase in volume compared to the normal hindlimb, with statistical significance at day 5. This volume increase tends to be maintained after radiotherapy at 14 days, but this difference is lost at 56 days. (b) Lymphoscintigraphy shows an improvement in lymphatic flow after cell therapy as demonstrated by the collection of radioactive materials (red circles) in the proximal parts of the body compared to the other groups.