Research Article

Identification of Interconnected Markers for T-Cell Acute Lymphoblastic Leukemia

Table 13

The genes common to subnetwork genes and the 200 most differentially expressed genes.

Gene symbolGene titleGO: functionGO: process

ADD2Adducin 2 (beta)Actin binding, calmodulin binding, and metal-ion bindingNo enrichments

CD36CD36 molecule (thrombospondin receptor)Lipoprotein binding, low-density lipoprotein receptor activity, and receptor activityBlood coagulation, cell adhesion, lipid metabolic process, lipoprotein transport, and transport

CLUClusterinProtein bindingAntiapoptosis, apoptosis, cell death, complement activation, classical pathway, endocrine pancreas development, innate immune response, lipid metabolic process, neurite morphogenesis, positive regulation of cell differentiation, positive regulation of cell proliferation, and response to oxidative stress

GSNGelsolin (amyloidosis, Finnish type)Actin binding, calcium ion binding, and protein bindingActin filament polymerization, actin filament severing, and barbed-end actin filament capping

ITGA2BIntegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)Calcium ion binding, identical protein binding, protein binding, and receptor activityCell adhesion, cell adhesion, and integrin-mediated signaling pathway

LTB4RLeukotriene B4 receptorLeukotriene B4 receptor activity, nucleotide binding, and receptor activityG-protein signaling, coupled to IP3 second messenger (phospholipase C activating), cell motility, immune response, inflammatory response, muscle contraction, and signal transduction

TLR4Toll-like receptor 4Lipopolysaccharide binding, protein binding, and transmembrane receptor activityI-kappaB kinase/NF-kappaB cascade, T-helper 1 type immune response, detection of fungus, inflammatory response, innate immune response, macrophage activation, negative regulation of osteoclast differentiation, positive regulation of interleukin-12 biosynthetic process, positive regulation of interleukin-12 biosynthetic process, positive regulation of interleukin-8 biosynthetic process, positive regulation of tumor necrosis factor biosynthetic process, and signal transduction

TUBB1Tubulin, beta-1GTP binding, GTPase activity, nucleotide binding, and structural molecule activityMicrotubule-based movement, protein polymerization