Comparison of International Normalized Ratio Measurement between CoaguChek XS Plus and STA-R Coagulation Analyzers

Table 2

Previous studies on the performances of CoaguChek XS Plus system.

Study	Number of measurements	Setting	Laboratory-based system	Comparison using Bland-Altman plot,; mean bias (95% limit of agreement)
Deom et al. (2009) [13]	259	Community setting; (38 doctor’s offices)	Innovin (Siemens/Dade-Behring)	0.03 INR (−0.67 INR ~ 0.74 INR)
Urwyler et al. (2009) [14]	227	Perioperative setting	Innovin (Siemens/Dade-Behring)	2.3% (95% CI = −20.3% ~ 24.9%)
Donaldson et al. (2010) [10]	52	Pharmacist-managed anticoagulation clinic	Stago (Diagnostica-stago)	0.27 INR (−0.33 INR ~ 0.88 INR)
Celenza and Skinner (2011) [15]	293	Emergency department	Not specified	−0.0 INR (−1.1 INR ~ 1.1 INR)
Lawrie et al. (2012) [16]	168 for innovin and 115 for PT-Fib HS+	Overanticoagulated (INR > 4.5) patients in anticoagulation clinic	Innovin (Siemens/Dade-Behring) on CA-7000 analyzer (Sysmex) and PT-Fib HS+ (Instrumentation Laboratory) on CA-1500 analyzer (Sysmex)	Innovin: −0.1% (−22.0% ~ 22.1%); PT-Fib HS+: 8.2% (−21.4% ~ 37.9%)
Urwyler et al. (2012) [17]	73	Pediatric intensive care unit setting	Innovin (Siemens/Dade-Behring)	1.22% (−27% ~ 56%)

Abbreviations: INR: international normalized ratio; SD: standard deviation; CI: confidence interval; PT-Fib HS+: HemosIL PT-Fibrinogen HS Plus.