Association of Genetic Variants of BMP4 with Type 2 Diabetes Mellitus and Clinical Traits in a Chinese Han Population
Table 2
Associations of BMP4 SNPs with type 2 diabetes.
SNP
Chr. position (Build 37.3)
Major/minor allele
Risk allele
Cases ()
Controls ()
OR for risk allele (95% CI)
P value for risk allele
OR for genotype (95% CI)
P value for genotype (empirical P value)
Risk allele frequencies
Genotype count 11/12/22#
Risk allele frequencies
Genotype count 11/12/22#
rs1951867
54407192
G/C
G
0.903
2748/586/35
0.896
2673/617/36
1.073 (0.959, 1.201)
0.220
1.071 (0.957, 1.198)
0.233
rs7146040
54407920
A/G
G
0.097
2755/586/36
0.096
2768/572/38
1.017 (0.908, 1.140)
0.767
0.983 (0.878, 1.101)
0.769
rs4444235
54410919
T/C
C
0.459
996/167/717
0.452
1034/1593/716
1.026 (0.959, 1.098)
0.461
0.975 (0.912, 1.043)
0.465
rs17563
54417522
T/C
T
0.720
1800/1319/273
0.717
1733/1375/269
1.042 (0.967, 1.124)
0.280
1.042 (0.967, 1.123)
0.283
rs2071047
54418411
C/T
T
0.368
1380/1522/485
0.355
1428/1527/444
1.056 (0.985, 1.133)
0.126
0.948 (0.885, 1.016)
0.131
rs2761887
54425052
C/A
A
0.519
793/1675/920
0.511
795/1674/866
1.033 (0.965, 1.105)
0.348
0.968 (0.905, 1.036)
0.348
rs8014071
54431500
A/G
G
0.350
1426/1572/404
0.341
1462/1539/386
1.039 (0.968, 1.115)
0.290
0.962 (0.896, 1.033)
0.287
rs8014363
54431575
T/C
T
0.884
2617/690/45
0.873
2574/774/45
1.108 (0.999, 1.229)
0.051
1.110 (1.000, 1.231)
0.050 (0.3689)
rs7141785
54433114
C/T
C
0.904
2740/572/36
0.902
2727/594/32
1.028 (0.916, 1.154)
0.639
1.022 (0.912, 1.146)
0.705
rs6572927
54433390
T/A
T
0.633
1345/1534/456
0.632
1327/1533/455
1.008 (0.940, 1.082)
0.816
1.008 (0.939, 1.081)
0.834
P values <0.1 were shown in bold. The additive model was used in the association analyses between genotype and type 2 diabetes. 11: major allele homozygotes; 12: heterozygotes; 22: minor allele homozygotes. Empirical P values are for the alleles based on 10,000 permutations.
