Polymorphism of the Transferrin Gene in Eye Diseases: Keratoconus and Fuchs Endothelial Corneal Dystrophy

Table 1

Characteristics of keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD) patients and controls enrolled in this study.

Feature	Controls (𝑛=228)		KC (𝑛=216)		P	FECD (𝑛=130)		P
	Number	Frequency	Number	Frequency		Number	Frequency
Sex
Females	148	0.65	66	0.31	<0.001	93	0.72	0.20
Males	80	0.35	150	0.69		37	0.28
Age
Mean ± SD	61.92±19.77		36.24±11.78		<𝟎.𝟎𝟎𝟏^∗	70.00±10		<𝟎.𝟎𝟎𝟏^∗
Range	19–100		14–63			37–91
Smoking
Yes (current/former)	84	0.42	69	0.32	0.324	42	0.32	0.453
Never	144	0.58	147	0.68		88	0.68
KC/FECD in family
Yes	9	0.04	26	0.12	0.0028	13	0.10	0.039
No	219	0.96	190	0.88		117	0.90
BMI
≤25	99	0.44	97	0.45	0.986	51	0.40	0.513
25–30	74	0.33	71	0.33		41	0.32
≥30	51	0.23	48	0.22		36	0.28
Visual impairment
Yes	150	0.66	158	0.73	0.114	129	0.99	<0.001
No	78	0.34	58	0.27		1	0.01
Allergies
Yes	33	0.14	62	0.29	0.0004	21	0.17	0.784
No	195	0.86	154	0.71		109	0.83
Heart and vascular diseases
Yes	115	0.50	46	0.21	<0.001	82	0.63	0.028
No	113	0.50	170	0.79		48	0.37

P values for two-side χ ² test, except *P values for t-test; 𝑃<0.05 are in bold.