Polymorphism of the Transferrin Gene in Eye Diseases: Keratoconus and Fuchs Endothelial Corneal Dystrophy
Table 3
Distribution of genotypes and alleles of the g.3296G>A, g.3481A>G, and c.–2G>A polymorphisms of the TF gene and odds ratio (OR) with 95% confidence interval (95% CI) in patients with keratoconus (KC) and controls.
Polymorphism Genotype/allele
Controls ()
KC ()
Crude OR (95% CI)
P
Adjusted OR (95% CI)
P
Number
Frequency
Number
Frequency
g.3296G>A
G/G
103
0.45
82
0.38
0.74 (0.50–1.08)
0.114
0.64 (0.42–1.00)
0.048
G/A
115
0.50
106
0.49
0.96 (0.66–1.39)
0.809
1.09 (0.71–1.66)
0.708
A/A
10
0.04
28
0.13
3.23 (1.53–6.83)
0.002
3.22 (1.40–7.42)
0.006
;
G
320
0.70
270
0.62
0.68 (0.50–0.91)
0.011
0.62 (0.44–0.88)
0.007
A
134
0.30
162
0.38
1.52 (1.12–2.05)
0.007
1.66 (1.17–2.35)
0.005
g.3481A>G
A/A
62
0.27
68
0.31
1.23 (0.82–1.85)
0.321
1.34 (0.84–2.13)
0.225
A/G
132
0.58
106
0.49
0.70 (0.48–1.02)
0.063
0.64 (0.42–0.99)
0.043
G/G
34
0.15
42
0.19
1.38 (0.84–2.26)
0.206
1.41 (0.80–2.48)
0.230
A
256
0.56
242
0.56
0.99 (0.75–1.31)
0.969
1.02 (0.75–1.40)
0.885
G
200
0.44
190
0.44
1.00 (0.76–1.33)
0.969
0.98 (0.72–1.33)
0.885
c.–2G>A
G/G
61
0.27
68
0.31
1.23 (0.82–1.84)
0.327
1.31 (0.82–2.07)
0.257
G/A
128
0.56
104
0.48
0.73 (0.50–1.05)
0.092
0.69 (0.45–1.05)
0.084
A/A
39
0.17
44
0.20
1.24 (0.77–1.99)
0.378
1.23 (0.72–2.12)
0.451
;
G
250
0.55
240
0.56
1.05 (0.80–1.38)
0.719
1.09 (0.80–1.48)
0.605
A
206
0.45
192
0.44
0.97 (0.74–1.27)
0.822
0.94 (0.69–1.28)
0.693
along with corresponding ORs are in bold; aOR adjusted for heart and vascular diseases, allergies, sex, and family history for KC.
