Research Article

Metabolite Profile Resulting from the Activation/Inactivation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-Methyltetrahydro-β-carboline by Oxidative Enzymes

Figure 6

Metabolites and rates produced from 2-methyl-1,2,3,4-tetrahydro-β-carboline (2-Me-THβC) by cytochrome P450 2D6 (a) and lactoperoxidase (LPO) and myeloperoxidase (MPO) (b). (c) Corresponds to the formation of MPP+ from MPDP+ as catalyzed by peroxidases LPO and MPO (the corresponding controls with H2O2 and no enzyme are subtracted). Enzyme assays were as indicated in experimental section.
248608.fig.006a
(a) P450 2D6
248608.fig.006b
(b) Heme peroxidases
248608.fig.006c
(c) Heme peroxidases