Molecular Modeling of Lectin-Like Protein from Acacia farnesiana Reveals a Possible Anti-Inflammatory Mechanism in Carrageenan-Induced Inflammation
Figure 4
Antiinflammatory activity of AFAL. (a) Anti-inflammatory effect of A. farnesiana on carrageenan-induced peritonitis in mice. Mice were treated with saline (0.1 mL, i.v.) or AFAL (1 mg/kg, i.v., 15 minutes before) and then injected i.p. with carrageenan at a dose of 500 μg/cavity. The neutrophil migration was evaluated 4 h later. The white bars represent the neutrophil migration induced by saline injected i.p. The values are means ± SD. * compared to carrageenan group. (b) AFAL reduces vascular permeability on carrageenan-induced peritonitis in mice. Effects of the pretreatment with AFAL on vascular permeability. Vehicle (saline) or AFAL (1 mg/kg) was injected i.v. and, 15 minutes later, carrageenan (500 μg/cavity) was injected. The values are means ± SD. * compared to carrageenan group.
