Genetics of Alzheimer’s Disease

Table 1

Late-onset Alzheimer’s disease associated genes/variants.

Variant	Gene	Abbreviation	Risk/protective
rs7412	Apolipoprotein E	APOE	Risk
rs429358	Apolipoprotein E	APOE	Protective
rs744373	Bridging integrator 1	BIN1	Risk
rs11136000	Clusterin	CLU	Protective
rs3764650	ATP-binding cassette, subfamily A (ABC1), member 7	ABCA7	Risk
rs3818361	Complement component (3b/4b) receptor 1 (Knops blood group)	CR1	Risk
rs3851179	Phosphatidylinositol binding clathrin assembly protein	PICALM	Protective
rs610932	Membrane-spanning 4 domains, subfamily A, member 6A	MS4A6A	Protective
rs3865444	CD33 molecule	CD33	Protective
rs670139	Membrane-spanning 4 domains, subfamily A, member 4E	MS4A4E	Risk
rs9349407	CD2-associated protein	CD2AP	Risk

Each of the top variants associated with late-onset Alzheimer’s disease from meta-analysis done by the Alzheimer Research Forum is listed here, together with the specific associated variant, and whether the variant increases risk or provides protection.