Mesenchymal Stem Cell-Like Cells Derived from Mouse Induced Pluripotent Stem Cells Ameliorate Diabetic Polyneuropathy in Mice

Figure 6

Plantar skin blood flow and capillary number in a soleus muscle. (a) Plantar skin blood flow in diabetic mice significantly decreased compared with that in nondiabetic mice. The flow was ameliorated in transplanted mice. ^#𝑃<0.05 compared with pretransplanted nondiabetic mice, ^‡𝑃<0.05 compared with posttransplanted mice, ^∗𝑃<0.05 compared with non-T. D: diabetic mice, N: nondiabetic mice, con-T: contralateral limbs of transplanted mice, ipsi-T: ipsilateral limbs of transplanted mice. 𝑛=7--12 in each group. (b, c) In a soleus muscle, capillaries were visualized with isolectin GS-IB4 (red). Quantification of the capillary-to-muscle number ratio revealed the increase of the ratio in transplanted limbs. ^∗𝑃<0.05 compared with con-T. con-T: contralateral limbs of transplanted mice, ipsi-T: ipsilateral limbs of transplanted mice. 𝑛=4 in each group.

(a)

(b)

(c)