Antioxidant Capacity and Antimutagenic Potential of Murraya koenigii
Table 2
Effect of benzene fraction of Murraya koenigii on the mutagenicity induced by sodium azide (NaN3) using Salmonella typhimurium strains.
Treatment
Dose (µg/plate)
Number of His+ revertants colonies/plate
TA97a
TA98
TA100
TA102
Spontaneous
140.0 ± 4.0
31.0 ± 3.6
128.7 ± 9.8
245.7 ± 23.3
Positive control (NaN3)
1.5
246.3 ± 16.0
52.7 ± 2.1
352.0 ± 33.0
343.3 ± 33.3
Murraya koenigii
12.5
164.3 ± 12.3
46.0 ± 4.0
191.7 ± 13.3
286.7 ± 26.3
25
145.0 ± 15.5
37.3 ± 7.0
172.3 ± 18.9
260.0 ± 24.1
50
124.7 ± 9.1
30.7 ± 8.5
153.0 ± 19.7
245.3 ± 24.4
100
118.0 ± 10.5
24.0 ± 4.6
127.0 ± 15.5
228.3 ± 19.6
Murraya koenigii + NaN3
12.5
225.3 ± 33.6 (25.6)
51.3 ± 6.0 (20.0)
316.3 ± 32.0 (22.3)
332.3 ± 34.9 (19.4)
25
200.7 ± 22.7* (45.1)
45.3 ± 4.2 (47.8)
258.0 ± 29.6* (52.3)
313.0 ± 32.1 (36.4)
50
168.0 ± 22.3** (64.4)
39.0 ± 8.2* (62.1)
212.7 ± 26.6** (70.0)
292.7 ± 18.6 (51.7)
100
137.3 ± 12.7*** (84.9)
31.7 ± 6.5** (73.2)
162.0 ± 21.0** (84.4)
260.3 ± 14.0* (72.2)
value
18.069
8.288
33.690
6.917
value
0.999
0.953
0.969
0.996
The data represented in the table is the mean ± SD values of three replicates. Mean values followed by asterisk are significantly different when compared to positive control at *P < 0.05, **P < 0.005, and ***P < 0.001. The values in parentheses are the inhibition rates of mutagenicity (%). Positive control: NaN3, sodium azide. aNegative control; bpreincubation test; : linear regression analysis.
