A Novel Framework for the Identification and Analysis of Duplicons between Human and Chimpanzee

Table 5

GO analysis of biological process at levels 2 and 3. 𝑃 values are computed by chi-square test with Bonferroni correction.

GO term	GO category	P value	Obs./exp.
Level 2
GO:0000003	Metabolic process	4.36×10^−9	0.75
GO:0001906	Multicellular organismal process	8.22×10^−8	1.36
GO:0002376	Biological adhesion	1.10×10^−6	0.28
GO:0008152	Cellular process	3.53×10^−6	1.16
GO:0009987	Developmental process	4.35×10^−6	1.33
GO:0010926	Positive regulation of biological process	4.70×10^−3	1.38
GO:0016032	Regulation of biological process	1.90×10^−2	0.86
GO:0022414	Locomotion	2.80×10^−2	0.44
Level 3
GO:0048856	Anatomical structure development	1.40×10^−13	1.71
GO:0051239	Regulation of multicellular organismal process	6.28×10^−13	2.33
GO:0043170	Macromolecule metabolic process	1.53×10^−9	0.65
GO:0009058	Biosynthetic process	2.64×10^−9	0.57
GO:0002682	Regulation of immune system process	1.10×10^−8	2.70
GO:0019222	Regulation of metabolic process	1.74×10^−8	0.53
GO:0007275	Multicellular organismal development	8.82×10^−8	1.53
GO:0048518	Positive regulation of biological process	5.32×10^−7	1.68
GO:0007154	Cell communication	4.69×10^−6	0.65
GO:0001816	Cytokine production	4.98×10^−6	2.89
GO:0051656	Establishment of organelle localization	6.84×10^−6	4.29
GO:0045321	Leukocyte activation	1.35×10^−5	2.44
GO:0032879	Regulation of localization	3.90×10^−5	2.14
GO:0044238	Primary metabolic process	1.62×10^−4	0.77
GO:0001775	Cell activation	1.92×10^−4	2.21
GO:0055114	Oxidation reduction	2.17×10^−4	0.15
GO:0048583	Regulation of response to stimulus	5.14×10^−4	2.24
GO:0051050	Positive regulation of transport	6.46×10^−4	2.84
GO:0007155	Cell adhesion	1.08×10^−3	0.34
GO:0032898	Neurotrophin production	6.88×10^−3	18.9
GO:0060033	Anatomical structure regression	1.81×10^−2	9.47
GO:0008283	Cell proliferation	2.39×10^−2	0.45