Pharmacokinetics and Bioequivalence Evaluation of Cyclobenzaprine Tablets

Table 2

Pharmacokinetic parameters after oral administration of 10 mg cyclobenzaprine tablets to healthy volunteers.

	AUC; (ng*h/mL)	𝐶max; (ng/mL)	𝑇max; (h)	𝑉𝑑; (L)	Cl; (L/h)	𝐾𝛽  (h^−1)	𝑡(1/2)𝛽 (h)	𝐾𝛾; (h^−1)	𝑡(1/2)𝛾  (h)	MRT; (h)
Average	200.5	7.1	4.5	146.2	33.1	0.247	3.1	0.024	31.9	34.7
SD	93.6	2.3	1.3	81.6	14.0	0.088	1.0	0.008	8.9	10.4
CV (%)	46.7	33.0	29.2	55.8	42.2	35.8	31.4	33.2	28.0	30.0
Median	182.8	6.8	5.0	118.2	30.1	0.232	3.0	0.022	31.1	33.3
Minimum	84.3	3.2	2.0	34.2	10.7	0.137	1.3	0.013	14.2	16.3
Maximum	512.9	11.4	7.0	354.5	65.3	0.524	5.1	0.049	51.7	56.3

AUC: area under concentration—time curve; 𝐶_max: peak drug concentration; 𝑇_max: time to reach 𝐶_max; 𝑉_𝑑: distribution volume; Cl: drug clearance after oral administration; 𝐾_𝛽: rapid elimination rate constant; 𝑡_(1/2)𝛽: rapid elimination half-life; 𝐾_𝛾: terminal elimination rate constant; 𝑡_(1/2)𝛾: terminal elimination half-life; MRT: mean residence time; SD: standard deviation; CV: coefficient of variation.