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BioMed Research International
Volume 2013, Article ID 285063, 7 pages
Research Article

MicroRNA-Mediated Regulation in Biological Systems with Oscillatory Behavior

1Department of Mathematics, Shanghai University, Shanghai 200444, China
2Institute of Systems Biology, Shanghai University, Shanghai 200444, China

Received 30 April 2013; Revised 3 June 2013; Accepted 4 June 2013

Academic Editor: Tao Huang

Copyright © 2013 Zhiyong Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As a class of small noncoding RNAs, microRNAs (miRNAs) regulate stability or translation of mRNA transcripts. Some reports bring new insights into possible roles of microRNAs in modulating cell cycle. In this paper, we focus on the mechanism and effectiveness of microRNA-mediated regulation in the cell cycle. We first describe two specific regulatory circuits that incorporate base-pairing microRNAs and show their fine-tuning roles in the modulation of periodic behavior. Furthermore, we analyze the effects of miR369-3 on the modulation of the cell cycle, confirming that miR369-3 plays a role in shortening the period of the cell cycle. These results are consistent with experimental observations.