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BioMed Research International
Volume 2013, Article ID 287696, 6 pages
Research Article

A Retrospective Longitudinal Cohort Study of Antihypertensive Drug Use and New-Onset Diabetes in Taiwanese Patients

1Department of Pharmacy, China Medical University Hospital, Beikang Campus, Taichung 40402, Taiwan
2Institute of Pharmacy, China Medical University, Taichung 40402, Taiwan
3Department of Health Services Administration, China Medical University, Taichung 40402, Taiwan
4Central Region Branch, Bureau of National Health Insurance, Taichung 40709, Taiwan
5Yuan Rung Hospital, Changhua 51043, Taiwan
6Division of Internal Cardiology, Armed Forces Taichung General Hospital, and Basic Science, Central Taiwan University of Science and Technology, Taichung 41168, Taiwan

Received 27 August 2012; Revised 28 October 2012; Accepted 6 November 2012

Academic Editor: Joseph Fomusi Ndisang

Copyright © 2013 Ching-Ya Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Antihypertensive drugs have been linked to new-onset diabetes (NOD); however, data on the effect of these drugs on the development of NOD in hypertensive patients has not been well determined in a clinical setting. The aim was to investigate the association between antihypertensive drugs and NOD in Taiwan. We conducted a retrospective study of hypertensive Taiwanese patients receiving antihypertensive drugs treatment between January 2006 and December 2011. Clinical information and laboratory parameters were collected by reviewing the medical records. We estimated the odds ratios (ORs) of NOD associated with antihypertensive drug use; nondiabetic subjects served as the reference group. A total of 120 NOD cases were identified in 1001 hypertensive patients during the study period. The risk of NOD after adjusting sex, age, baseline characteristics, and lipid profiles was higher among users of thiazide diuretics (OR, 1.65; 95% confidence interval (CI), 1.12–2.45) and nondihydropyridine (non-DHP) calcium channel blockers (CCBs) (OR, 1.96; 95% CI, 1.01–3.75) than among nonusers. Other antihypertensive drug classes were not associated with risk of NOD. Our results show that patients with hypertension who take thiazide diuretics and non-DHP CCBs are at higher risk of developing NOD than those who take other classes of antihypertensive drugs in Taiwan.