Colon Targeted Guar Gum Compression Coated Tablets of Flurbiprofen: Formulation, Development, and Pharmacokinetics

Table 1

Composition and characterization of FLB core tablets

Ingredients	Quantity (mg)	Core tablet evaluation parameters	𝑛	Observed values
Flurbiprofen	100	Weight variation (mg)	20	174.85±2.92
Spray dried lactose	50.5	Core thickness (mm)	20	3.01±0.02
Crospovidone	17.5	Core diameter (mm)	20	7.04±0.01
Sodium lauryl sulphate	1.75	Hardness (kg/cm^2)	6	2.83±0.35
Talc	3.5	Friability (%)	10	0.58
Magnesium stearate	1.75	Disintegration time (sec)	3	35.67±3.51
Core weight	175	Content uniformity (%)	3	100.28±1.12
		% drug release in 15 min (𝑄15)	3	99.59±0.69