Colon Targeted Guar Gum Compression Coated Tablets of Flurbiprofen: Formulation, Development, and Pharmacokinetics

Table 4

Release kinetics of FLB-GG compression coated tablets.

Formulation	Zero order		First order		Higuchi
	𝐾0 (mg/hr)	𝑅^2	𝐾1 (hr^−1)	𝑅^2	𝐾 (mg/hr^−1/2)	𝑅^2
F1	24.59	0.960	1.14689	0.920	44.28	0.823
F2	21.33	0.978	0.91199	0.898	44.06	0.854
F3	3.333	0.971	0.17503	0.808	16.70	0.872
F4	3.391	0.963	0.17733	0.797	17.05	0.872
F5	1.798	0.948	0.1566	0.755	9.246	0.897

𝐾₀: zero-order rate constant, 𝐾₁: first-order rate constant, 𝐾: higuchi model rate constant, and 𝑅²: correlation coefficient.