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BioMed Research International
Volume 2013, Article ID 292865, 5 pages
http://dx.doi.org/10.1155/2013/292865
Clinical Study

Efficacy of Triptolide for Children with Moderately Severe Henoch-Schönlein Purpura Nephritis Presenting with Nephrotic Range Proteinuria: A Prospective and Controlled Study in China

1Department of Nephrology, The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
2Department of Pediatrics, The Second People’s Hospital of Linhai, Linhai, Zhejiang 317016, China

Received 10 October 2013; Accepted 2 December 2013

Academic Editor: Masayuki Iyoda

Copyright © 2013 Li Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To observe the clinical efficacy of the Chinese herb, Triptolide, in children with moderately severe Henoch-Schönlein purpura nephritis (HSPN). Methods. From January 2007 to December 2011, 56 HSPN children manifested by nephrotic range proteinuria with normal kidney function and 50% crescents or sclerosing lesions on biopsy were hospitalized in the Children’s Hospital of Zhejiang University School of Medicine. They were divided into two groups: the treatment group ( ; Triptolide at a dosage of 1 mg/kg·d, combined with prednisone at a dosage of 2 mg/kg·d, within a course of medium-to-long-term therapy of 6 to 9 months) and the control group ( ; prednisone alone, with the same procedure). Results. Short-term remission was observed in 95% of patients from treatment group and in 72% of patients from control group, respectively. There was a significant difference between both groups ( , ) for short-term effects. Meanwhile, no significant difference, as proteinuria, hematuria, hypertension, and decreased eGFR, was observed between the two groups in long-term followup ( , ). The Kaplan-Meier plot analysis also revealed no significant difference ( , ). Conclusion. Triptolide is effective in relieving short-term symptoms for moderately severe HSPN children, though its long-term effects need to be observed further.