The Synergistic Effects of Low Dose Fluorouracil and TRAIL on TRAIL-Resistant Human Gastric Adenocarcinoma AGS Cells

Table 1

Synergistic effect of TRAIL combined with 5-Fu on AGS cells analyzed by Jin’s formula (𝑄 value listed in the table).

5-Fu (𝜇g/mL)	TRAIL (𝜇g/mL)
	0.4	2	10	50
0.05	0.88	0.95	0.91	0.84
0.1	0.94	0.99	0.92	0.91
0.5	1.03	1.20^#	1.06	0.98
1	1.15^#	1.17^#	1.12	1.12
5	1.16^#	1.22^#	1.17^#	1.02

According to Jin’s formula, 𝑄<0.85 indicates antagonism, 0.85≤𝑄<1.15 indicates additive effects, and 𝑄≥1.15 indicates synergism (^#). Synergism indicates that the effect of a mixture exceeds that expected from the individual components and additive effects (noninteraction) mean that the combined effect is equal to the expectation.