BioMed Research International / 2013 / Article / Fig 1

Research Article

Defects in Base Excision Repair Sensitize Cells to Manganese in S. cerevisiae

Figure 1

Dose-dependent response of selected yeast strains to Mn2+. Wild-type parental strain (BY4741) was tested for growth on media after exposure to 0, 0.5, 1.5, 2.5, and 5 mM Mn2+ as indicated in Materials and Methods. Survival was determined by counting the number of colonies in the respective dilutions and calculated based on the growth of cells not exposed to Mn2+ (100% survival). Mutant strains ntg1 and hsp104 that display increased and reduced sensitivity to Mn2+, respectively, are shown for comparison. The curve was fitted by nonlinear Sigmoidal dose response (variable slope).

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